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📙 Carbohydrate-Based Drug Discovery by — pdf free


Content:
Chapter 1 Synthetic Methodologies (pages 1–36): Chikako Saotome and Osamu Kanie
Chapter 2 Complex Carbohydrate Synthesis (pages 37–54): Makoto Kiso, Hideharu Ishida and Hiromune Ando
Chapter 3 The Chemistry of Sialic Acid (pages 55–102): Geert?Jan Boons and Alexei V. Demchenko
Chapter 4 Solid?Phase Oligosaccharide Synthesis (pages 103–127): Peter H. Seeberger
Chapter 5 Solution and Polymer?Supported Synthesis of Carbohydrates (pages 129–136): Shin?Ichiro Nishimura
Chapter 6 Enzymatic Synthesis of Oligosaccharides (pages 137–167): Jianbo Zhang, Jun Shao, Prezemk Kowal and Peng George Wang
Chapter 7 Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology (pages 169–214): Oliver Seitz
Chapter 8 Synthesis of Complex Carbohydrates: Everninomicin (pages 215–252): K. C. Nicolaou, Helen J. Mitchell and Scott A. Snyder
Chapter 9 Chemical Synthesis of Asparagine?Linked Glycoprotein Oligosaccharides: Recent Examples (pages 253–280): Yukishige Ito and Ichiro Matsuo
Chapter 10 Chemistry and Biochemistry of Asparagine?Linked Protein Glycosylation (pages 281–303): Barbara Imperiali and Vincent W.?F. Tai
Chapter 11 Conformational Analysis of C?Glycosides and Related Compounds: Programming Conformational Profiles of C? and O?Glycosides (pages 305–340): Peter G. Goekjian, Alexander Wei and Yoshito Kishi
Chapter 12 Synthetic Lipid A Antagonists for Sepsis Treatment (pages 341–355): William J. Christ, Lynn D. Hawkins, Michael D. Lewis and Yoshito Kishi
Chapter 13 Polysialic Acid Vaccines (pages 357–380): Harold J. Jennings
Chapter 14 Synthetic Carbohydrate?Based Vaccines (pages 381–406): Stacy J. Keding and Samuel J. Danishefsky
Chapter 15 Chemistry, Biochemistry, and Pharmaceutical Potentials of Glycosaminoglycans and Related Saccharides (pages 407–439): Tasneem Islam and Robert J. Linhardt
Chapter 16 A New Generation of Antithrombotics Based on Synthetic Oligosaccharides (pages 441–459): Maurice Petitou and Jean?Marc Herbert
Chapter 17 Sequencing of Oligosaccharides and Glycoproteins (pages 461–482): Stuart M. Haslam, Kay?Hooi Khoo and Anne Dell
Chapter 18 Preparation of Heterocyclic 2?Deoxystreptamine Aminoglycoside Analogues and Characterization of Their Interaction with RNAs by Use of Electrospray Ionization Mass Spectrometry (pages 483–499): Richard H. Griffey, Steven A. Hofstadler and Eric E. Swayze
Chapter 19 Glycosylation Analysis of a Recombinant P?Selectin Antagonist by High?pH Anion?Exchange Chromatography with Pulsed Electrochemical Detection (HPAEC/PED) (pages 501–516): Mark R. Hardy and Richard J. Cornell
Chapter 20 Analytical Techniques for the Characterization and Sequencing of Glycosaminoglycans (pages 517–539): Ram Sasisekharan, Zachary Shriver, Mallik Sundaram and Ganesh Venkataraman
Chapter 21 Thermodynamic Models of the Multivalency Effect (pages 541–574): Pavel I. Kitov and David R. Bundle
Chapter 22 Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes (pages 575–608): Laura L. Kiessling, Jason K. Pontrello and Michael C. Schuster
Chapter 23 Glycosyltransferase Inhibitors (pages 609–659): Karl?Heinz Jung and Richard R. Schmidt
Chapter 24 RNA?Aminoglycoside Interactions (pages 661–683): Haim Weizman and Yitzhak Tor
Chapter 25 Glycosylated Natural Products (pages 685–711): Jon S. Thorson and Thomas Vogt
Chapter 26 Novel Enzymatic Mechanisms in the Biosynthesis of Unusual Sugars (pages 713–745): Alexander Wong, Xuemei He and Hung?Wen Liu
Chapter 27 Neoglycolipids: Identification of Functional Carbohydrate Epitopes (pages 747–760): Ten Feizi, Alexander M. Lawson and Wengang Chai
Chapter 28 A Preamble to Aglycone Reconstruction for Membrane?Presented Glycolipid Mimics (pages 761–779): Murugesapillai Mylvaganam and Clifford A. Lingwood
Chapter 29 Small Molecule Inhibitors of the Sulfotransferases (pages 781–801): Dawn E. Verdugo, Lars C. Pedersen and Carolyn R. Bertozzi
Chapter 30 Carbohydrate?Based Treatment of Cancer Metastasis (pages 803–829): Reiji Kannagi
Chapter 31 N?Acetylneuraminic Acid Derivatives and Mimetics as Anti?Influenza Agents (pages 831–861): Robin Thomson and Mark von Itzstein
Chapter 32 Modified and Modifying Sugars as a New Tool for the Development of Therapeutic Agents – The Biochemically Engineered N?Acyl Side Chain of Sialic Acid: Biological Implications and Possible Uses in Medicine (pages 863–873): Rudiger Horstkorte, Oliver T. Keppler and Werner Reutter
Chapter 33 Modified and Modifying Sugars as a New Tool for the Development of Therapeutic Agents – Glycosidated Phospholipids as a New Type of Antiproliferative Agents (pages 875–882): Kerstin Danker, Annette Fischer and Werner Reutter
Chapter 34 Glycoside Primers and Inhibitors of Glycosylation (pages 883–898): Jillian R. Brown, Mark M. Fuster and Jeffrey D. Esko
Chapter 35 Carbohydrate?Based Drug Discovery in the Battle against Bacterial Infections: New Opportunities Arising from Programmable One?Pot Oligosaccharide Synthesis (pages 899–932): Thomas K. Ritter and Prof. Dr. Chi?Huey Wong

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  • Language: English
  • ISBN: 9783527306329,9783527602438

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