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📙 Genomics in Drug Discovery and Development by Dimitri Semizarov, Eric Blomme(auth.) — download pdf


Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.Content:
Chapter 1 Introduction: Genomics and Personalized Medicine (pages 1–24):
Chapter 2 Genomics Technologies as Tools in Drug Discovery (pages 25–103):
Chapter 3 Genomic Biomarkers (pages 105–166):
Chapter 4 Fundamental Principles of Toxicogenomics (pages 167–217):
Chapter 5 Toxicogenomics: Applications to In Vivo Toxicology (pages 219–291):
Chapter 6 Toxicogenomics: Applications in In Vitro Systems (pages 293–327):
Chapter 7 Germ Line Polymorphisms and Drug Response (pages 329–383):
Chapter 8 Pharmacogenetics of Drug Disposition (pages 385–421):
Chapter 9 Overview of Regulatory Developments and Initiatives Related to the Use of Genomic Technologies in Drug Discovery and Development (pages 423–448):

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