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📙 High throughput screening methods: evolution and refinement by Joshua A Bittker, Nathan T Ross, Tom Brown, Kira J Weissman, Claes Andersson, Douglas Auld, Peizin Zhu, Sean Ekins, Jaime Cheah, Mark Wigglesworth, Damien Young, Michael Mesleh, Greg Hoffman, Matthew Robers, Christopher Hale, Benjamin Haibe-Kains, Christopher Mader, Richard Eglen, Stephen Hale, Andrea deSouza, Rohan Beckwith — free epub


High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success.
Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions.
This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.



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